AiViva Biopharma Initiates Phase 1 Clinical Trial of AIV007 for Age-Related Macular Degeneration and Diabetic Macular Edema

  • Novel JEL™ Technology for Periocular Administration

COSTA MESA, Calif., May 22, 2023 (GLOBE NEWSWIRE) — AiViva Biopharma Inc., a clinical-stage biotechnology company, announced that it has begun a Phase 1 trial and completed dosing the first cohort of patients diagnosed with wet age-related macular degeneration (wAMD), and/or diabetic macular edema (DME).

“We are very excited to have initiated this U.S. trial,” said Diane Tang-Liu, PhD, CEO, President & Co-Founder of AiViva Biopharma. “AIV007 is a broad spectrum tyrosine kinase inhibitor, targeting the convergence of fibrosis, angiogenesis, and inflammation. We believe AIV007 coupled with our proprietary JEL™ technology and administered periocularly, will address the root causes of many ocular diseases.”

This Phase 1 trial is a multicenter, open-label, dose-escalation safety clinical trial. Up to 24 subjects will receive a single periocular injection and will undergo monthly evaluation for up to 6 months to assess safety, tolerability, and efficacy measured by best corrected visual acuity (BCVA).

About Age-Related Macular Degeneration and Diabetic Macular Edema
AMD is a progressive retinal disease that is the leading cause of blindness in adults over the age of 60, affecting up to 15 million U.S. people. AMD affects the macular, center portion of the retina, that is responsible for central vision and color perception. In patients with wet AMD vision loss is caused by abnormal blood vessels leaking fluid and blood into and beneath the retina.

Diabetic macular edema is manifested as retinal thickening and swelling caused by accumulation of intraretinal fluid usually due to blood sugar levels being consistently high. If untreated, chronic macular edema can lead to irreversible damage of the macula and permanent vision loss.

About AiViva Biopharma, Inc.
AiViva is a clinical stage biotech company led by a team of seasoned industry experts with proven track record in drug development and commercialization. AiViva has developed innovative approaches to address high unmet medical needs through focal therapies that target diseases of neovascularization, abnormal cell proliferation, and fibrosis. Core competencies include development of novel drugs using proprietary technologies, including JEL™, in specialty therapeutic areas of ophthalmology, dermatology, urology and oncology. Please visit www.aiviva.com to learn more.

Contact:
AiViva Biopharma
office@aiviva.com

GlobeNewswire Distribution ID 8843293

Bombardier Challenger 3500 Business Jet Makes European Debut at EBACE 2023

Bombardier’s Challenger 3500 Business Jet

Bombardier Challenger 3500 Business Jet Makes European Debut at EBACE 2023

  • The Challenger 3500 business jet, which will be on display at the European airshow, offers customers in the region a preview of Bombardier’s eco-design vision
  • The Challenger 3500 aircraft boasts the first eco app* solution available in business aviation, optimizing flight plans for a reduced environmental footprint
  • Passengers benefit from the ultimate cabin experience, with striking interior design, the widest cabin in its class, the renowned Nuage seat and the highly reliable Iridium Certus connectivity

GENEVA, May 22, 2023 (GLOBE NEWSWIRE) — Bombardier will debut the award-winning Challenger 3500 business jet to the European market, as all gather at the 2023 European Business Aviation Convention and Exhibition (EBACE) in Geneva, Switzerland. The Challenger 3500 aircraft, which entered service in September 2022, is showcased in grand style alongside the industry’s flagship, the Global 7500 aircraft, and a stunning Certified Pre-Owned Challenger 605 aircraft also making its debut.

The latest evolution in the Challenger lineage is a tangible gateway to Bombardier’s eco-design vision. In the cabin, the Challenger 3500 aircraft boasts a high-end product design by proposing a selection of innovative, sustainable materials that minimize the impact on the environment. The Challenger 3500 also joins the Global 5500, Global 6500 and Global 7500 aircraft in standing alone as the only business jets in the industry to carry an Environmental Product Declaration (EPD), offering trustworthy, thorough and transparent views of their environmental footprint.

“European customers will be able to feel for themselves the high quality that is standard for our aircraft – such as in experiencing Bombardier’s illustrious Nuage seat – all while finding unique design options that are genuinely more sustainable,’’ said Jean-Christopher Gallagher, Executive Vice President, Aircraft Sales & Bombardier Defense, Bombardier. “We are very proud to open the door of the Challenger 3500 aircraft to our European customers for the very first time. This top-of-the-line aircraft demonstrates that exceptional comfort, ultimate performance and lower environmental footprint can go hand in hand.’’

The stunning aircraft interior offers a host of new technologies, including the recently announced Iridium Certus connectivity, the industry’s first voice-controlled cabin, wireless chargers throughout the cabin, and the only 24-inch, 4K displays in its class. Thanks to its perfectly crafted cabin experience, the Challenger 3500 aircraft has received multiple accolades, including the Best of the Best honor at the prestigious Red Dot Awards for Product Design in 2022.

In the flight deck, the Challenger 3500 aircraft has more baseline features than any of its competitors, with a standard auto-throttle system to further enhance the experience for Challenger pilots. The introduction of the first eco app* solution in business aviation also enables optimized flight plans, which help operators save fuel and reduces the aircraft’s environmental footprint.

Beyond its exceptional features, reliability remains the Challenger family’s landmark. With over 890 business jets of the Challenger 300 series in service worldwide, totaling more than 3.6 million flight hours and more than 2.1 million landings, this iconic aircraft family is known for its proven reliability and excellent safety record.

About Bombardier

Bombardier (BBD-B.TO) is a global leader in aviation, focused on designing, manufacturing, and servicing the world’s most exceptional business jets. Bombardier’s Challenger and Global aircraft families are renowned for their cutting-edge innovation, cabin design, performance, and reliability. Bombardier has a worldwide fleet of approximately 5,000 aircraft in service with a wide variety of multinational corporations, charter and fractional ownership providers, governments, and private individuals. Bombardier aircraft are also trusted around the world in government and military special-mission roles leveraging Bombardier Defense’s proven expertise.

Headquartered in Greater Montréal, Québec, Bombardier operates aerostructure, assembly and completion facilities in Canada, the United States and Mexico. The company’s robust customer support network services the Learjet, Challenger and Global families of aircraft, and includes facilities in strategic locations in the United States and Canada, as well as in the United Kingdom, Germany, France, Switzerland, Italy, Austria, the UAE, Singapore, China and Australia.

For corporate news and information, including Bombardier’s Environmental, Social and Governance report, as well as the company’s plans to cover all its flight operations with Sustainable Aviation Fuel (SAF) utilizing the Book and Claim system visit bombardier.com. Learn more about Bombardier’s industry-leading products and customer service network at businessaircraft.bombardier.com. Follow us on Twitter @Bombardier.

Bombardier, Challenger, Challenger 300, Challenger 3500, Challenger 605, Global, Global 5500, Global 6500, Global 7500 and Nuage are registered or unregistered trademarks of Bombardier Inc. or its subsidiaries.

* Subject to availability. Subscription fees may apply. eWAS Pilot with OptiFlight® is a solution from SITA.

Visuals related to Bombardier’s announcements at EBACE are available here.

For Information

Marie-Andrée Charron
Bombardier
+1 514-441-2598
marie-andree.charron@aero.bombardier.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/b266ad7d-f3d2-4796-a4da-658366a9c609

GlobeNewswire Distribution ID 8843597

Bombardier Achieves Important Milestones on EcoJet Research Project, Continues Industry-Defining Work Toward Sustainable Aviation

Bombardier’s EcoJet Research Project

Bombardier’s EcoJet research project aims to develop and mature technologies to support a sustainable future for business aviation.

  • Bombardier successfully completes initial flight testing phase on the EcoJet research project, using a model of a blended-wing-body aircraft.
  • The subsequent phase of testing, focusing on flying a larger scaled model, is well underway.
  • The EcoJet research project aims to develop and mature technologies to support a sustainable future for business aviation.

GENEVA, May 22, 2023 (GLOBE NEWSWIRE) — Bombardier presented the progress made on its EcoJet research project, a research platform that aims to develop technologies with the goal of reducing aircraft emissions through a combination of advanced aerodynamics and propulsion enhancements. After several years of research, the organization successfully completed its first phase of testing with a small-scale model of a blended-wing-body aircraft, representing approximately 7% of a large business jet. Bombardier is now building on the significant knowledge acquired to engage in a second phase of testing with a model twice as large, and which completed its first flight last year to pave the way for this next test campaign.

“Bombardier has taken a leadership position in the industry’s efforts to reduce its environmental footprint, and the EcoJet research project is paramount to developing the technologies that will bring us toward the goal of net zero emissions by 2050,” said Stephen McCullough, Senior Vice President of Engineering and Product Development. “We are very pleased to see the highly engaging results yielded so far and to continue our trailblazing work as we kick off the next phase of this game-changing research project. The EcoJet research project has garnered a high level of interest across the industry, and we are looking forward to mobilizing partners as we continue to define the future of business aviation.”

Bombardier’s team noted highly positive results during the design optimization loops and initial flight test campaign. Those include the deployment of a next-generation Product Lifecycle Management (PLM) platform, the confirmation of a sixth-generation transonic wing modeling capability, and the demonstration of a new aircraft control architecture.

This research and technology project aims to reduce aircraft emissions by up to 50% through a combination of aerodynamic and propulsion enhancements. Renowned for its leading expertise and ingenuity, Bombardier created the EcoJet research project to develop and mature powerful technologies to leverage in future projects, as part of its firm commitment to a sustainable future for business aviation.

On top of its comprehensive EcoJet research project, Bombardier has taken several actions as part of its roadmap toward sustainable aviation. In the last three years, Bombardier published Environmental Product Declarations (EPD) for its Challenger 3500, Global 5500, Global 6500 and Global 7500 aircraft. These extensive declarations are the result of years of scientific efforts and are meant to act as tools for the aviation industry to drive sustainable innovations across its activities spectrum. Bombardier is also using Sustainable Aviation Fuel (SAF), at a 30% blend, to cover the totality of its flight operations, utilizing the Book-and-Claim system. The initiative will create a significant gain by reducing the annual greenhouse gas emissions associated with fuel used in Bombardier’s flight operations by approximately 25%.

About Bombardier

Bombardier (BBD-B.TO) is a global leader in aviation, focused on designing, manufacturing, and servicing the world’s most exceptional business jets. Bombardier’s Challenger and Global aircraft families are renowned for their cutting-edge innovation, cabin design, performance, and reliability. Bombardier has a worldwide fleet of approximately 5,000 aircraft in service with a wide variety of multinational corporations, charter and fractional ownership providers, governments, and private individuals. Bombardier aircraft are also trusted around the world in government and military special-mission roles leveraging Bombardier Defense’s proven expertise.

Headquartered in Greater Montréal, Québec, Bombardier operates aerostructure, assembly and completion facilities in Canada, the United States and Mexico. The company’s robust customer support network services the Learjet, Challenger and Global families of aircraft, and includes facilities in strategic locations in the United States and Canada, as well as in the United Kingdom, Germany, France, Switzerland, Italy, Austria, the UAE, Singapore, China and Australia.

For corporate news and information, including Bombardier’s Environmental, Social and Governance report, as well as the company’s plans to cover all its flight operations with Sustainable Aviation Fuel (SAF) utilizing the Book and Claim system visit bombardier.com. Learn more about Bombardier’s industry-leading products and customer service network at businessaircraft.bombardier.com. Follow us on Twitter @Bombardier.

Bombardier, Learjet, Challenger 3500, Global 5500, Global 6500 and Global 7500 are registered or unregistered trademarks of Bombardier Inc. or its subsidiaries.

Visuals related to Bombardier’s announcements at EBACE are available here.

For Information

Christina Lemyre McCraw
Manager, Public Relations and Communications
Bombardier
+1 514 497 4928
christina.lemyremccraw@aero.bombardier.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/55113615-49ee-4b0b-9513-b2cc1e82c97c

GlobeNewswire Distribution ID 8843576

Bombardier’s Certified Pre-Owned Aircraft Program Continues to Flourish, Showcases Pristine Challenger 605 Aircraft at EBACE 2023

Bombardier’s Certified Pre-Owned Challenger 605 aircraft

Bombardier’s Certified Pre-Owned Challenger 605 aircraft on display at EBACE

  • Bombardier’s CPO program has established a dynamic premium category for customers in the pre-owned business jet market
  • Customer interest has been overwhelmingly positive with several aircraft in service worldwide
  • CPO aircraft carry an exclusive one-year OEM warranty* and are selected by the team, inspected and updated with refurbished interiors, latest avionics and connectivity enhancements, and freshly completed maintenance

GENEVA, May 22, 2023 (GLOBE NEWSWIRE) — Bombardier today presented for the first time its turn-key Certified Pre-Owned aircraft program (CPO) by showcasing a pristine Challenger 605 aircraft at the European Business Aviation Convention & Exhibition (EBACE). Launched in mid-2021, Bombardier is the first OEM to introduce a refurbishment and upgrade offering for business jets – a premium class of pre-owned Learjet, Challenger and Global aircraft, that are selected, inspected and updated featuring refurbished interiors, fresh paint, upgraded avionics and connectivity systems, all specifically adhering to Bombardier’s highest quality and safety standards.

The stunning Challenger 605 jet featured at EBACE aptly illustrates the attributes of the CPO program, with its immaculate new interior and paint; brand-new Collins Pro Line 21 advanced avionics in the cockpit; industry-defining cost-per-flight-hour Smart Parts Preferred and Smart Link Plus connected aircraft programs enrolled ready; and Ka-Band cabin connectivity. Customer interest in Bombardier’s CPO program is gaining momentum – and with an annual average of 460 used Bombardier aircraft transacting over the past five years, there’s a healthy pool of aircraft to bring into the program.

“Bombardier customers wanted a certified option beyond the traditional pre-owned aircraft offering and our new CPO program certainly delivers on this premise,” said Paul Sislian, Executive Vice President, Bombardier Aftermarket Services and Strategy. “As the OEM, we are uniquely positioned to provide them with a best-in-class, turn-key certified aircraft solution – a new and exciting category in the industry.”

Bombardier’s Certified Pre-Owned aircraft are fully mission-capable upon delivery: they have airframe, engine and APU program coverage, an exclusive one-year OEM warranty*, and all applicable maintenance completed. All CPO products come with a Level 3 pre-buy inspection and are completed at Bombardier facilities around the world. And under Bombardier’s Smart Services coverage programs, customers receive turnkey solutions consistent with the program available for new aircraft buyers. Smart Services coverage programs are offered for Learjet, Challenger and Global aircraft.**

To ensure interested CPO customers have the latest pre-owned information at their fingertips, Bombardier has also created a dedicated pre-owned inventory web page with well-documented spec sheets describing in detail all the modifications, upgrades and maintenance completed on its CPO aircraft. It also produces a comprehensive Bombardier Pre-owned Market Report, highlighting the latest transaction trends, pre-owned inventory saturation levels and market commentaries for all pre-owned Bombardier aircraft.

Confirming Bombardier’s Certified Pre-Owned aircraft program is gaining traction, it is now fully recognized by appraisal authorities such as Aircraft Bluebook, Vref, and AircraftPost, who now report CPO aircraft in a distinct category from other pre-owned aircraft.

*One-year warranty on the airframe. Certain conditions apply.
** May not apply to all aircraft; certain conditions apply.

About Bombardier

Bombardier (BBD-B.TO) is a global leader in aviation, focused on designing, manufacturing, and servicing the world’s most exceptional business jets. Bombardier’s Challenger and Global aircraft families are renowned for their cutting-edge innovation, cabin design, performance, and reliability. Bombardier has a worldwide fleet of approximately 5,000 aircraft in service with a wide variety of multinational corporations, charter and fractional ownership providers, governments, and private individuals. Bombardier aircraft are also trusted around the world in government and military special-mission roles leveraging Bombardier Defense’s proven expertise.

Headquartered in Greater Montréal, Québec, Bombardier operates aerostructure, assembly and completion facilities in Canada, the United States and Mexico. The company’s robust customer support network services the Learjet, Challenger and Global families of aircraft, and includes facilities in strategic locations in the United States and Canada, as well as in the United Kingdom, Germany, France, Switzerland, Italy, Austria, the UAE, Singapore, China and Australia.

For corporate news and information, including Bombardier’s Environmental, Social and Governance report, as well as the company’s plans to cover all its flight operations with Sustainable Aviation Fuel (SAF) utilizing the Book and Claim system visit bombardier.com. Learn more about Bombardier’s industry-leading products and customer service network at businessaircraft.bombardier.com. Follow us on Twitter @Bombardier.

Bombardier, Certified Pre-Owned, Smart Parts Preferred, Smart Link Plus, Smart Services, Learjet, Challenger, Challenger 605 and Global are registered or unregistered trademarks of Bombardier Inc. or its subsidiaries.  Pro Line 21 is a trademark of Collins Aerospace.

Visuals related to Bombardier’s announcement at EBACE are available here.

For information

Matthew Nicholls
Sr. Public Affairs and Communications Advisor
Bombardier
+1 514-243-8214
Matthew.Nicholls@aero.bombardier.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/271da6d5-cbe3-405c-ac72-1f0f7aec38d6

GlobeNewswire Distribution ID 8843585

Khartoum sees cautious calm hours before new cease-fire comes into force

The Sudanese capital Khartoum on Monday morning witnessed a cautious calm hours before a new cease-fire is expected to take place between the Sudanese warring parties, Anadolu Agency reports. Since mid-April, the Sudanese army and the paramilitary Rapid Support Forces (RSF) have been exchanging heavy fire, accusing each other of starting assaults. According to an Anadolu reporter on the ground, heavy clashes were heard on Sunday night in several areas across Khartoum, including central Khartoum, the northern Bahri area, and Omdurman western Khartoum. On Sunday, Saudi Arabia and the United States announced that a new 7-day cease-fire has been agreed upon by the Sudanese rival groups starting as of Monday evening. Saudi Arabia said that talks in Jeddah city will continue with the aim to reach a permanent cease-fire and a conflict resolution through dialogue. Medical sources estimate that nearly 1,000 people have been killed during the war that erupted on April 15 between the Sudanese army and RSF. A disagreement had been fomenting in recent months between the army and the RSF over the paramilitary group’s integration into the armed forces, a key condition of Sudan’s transition agreement with political groups. Sudan has been without a functioning government since October 2021, when the military dismissed Prime Minister Abdalla Hamdok’s transitional government and declared a state of emergency in a move decried by political forces as a “coup.” Sudan’s transitional period, which started in August 2019 after the ouster of President Omar al-Bashir, had been scheduled to end with elections in early 2024.

Source: Azerbaijan State News Agency

Enjoying moment of victory at 39 European Championship in Rhythmic Gymnastics – Azerbaijani gymnasts and their mentors

A meeting with Azerbaijani gymnast – winners and prize-winners of the 39 European Championship in Rhythmic Gymnastics, held in Baku on May 17-21, was held at the National Gymnastics Arena on May 22, Trend reports.

The meeting was attended by members of the senior team in group exercises consisting of Gullu Aghalarzade, Laman Alimuradova, Kamilla Aliyeva, Zeynab Hummatova, Yelizaveta Luzan and Darya Sorokina, who won gold in exercises with three ribbons and two balls at the championship, as well as bronze in the all-around, and Zohra Aghamirova, who won the bronze medal in the program with the ball.

The event was also attended by the members of the Azerbaijan national rhythmic gymnastics team – Siyana Vasileva (coach), Yevgeniya Vilyaeva (coach and judge) and Kamil Guliyev (choreographer).

The opening speech at the event was delivered by Secretary General of the Azerbaijan Gymnastics Federation (AGF), Nurlana Mammadzada, who highlighted that the Azerbaijani national team won five medals at the 39th European Championship, and this is a historic result.

Noting that the First Vice-President of Azerbaijan, and President of the Azerbaijan Gymnastics Federation Mehriban Aliyeva shared on her Instagram account a publication on the occasion of the victory of the Azerbaijani team in group exercises at the championship in Baku, the gymnasts expressed gratitude for the support and congratulations, as well as for the opportunity to train and prepare for competitions in excellent conditions created in the arena.

Assessing the results of the championship, the coach of the team in group exercises Vasileva noted the successful performances of the Azerbaijani gymnasts.

“It’s quite difficult to perform at the home championship, there were worries and a lot of responsibility. At competitions, we compete with ourselves, our experiences, fears, and not with rivals. Yes, I analyze the performances of other teams to know their level. The goal of the coaches is to prepare the girls so that when they come out on the carpet, they show their maximum. For it, we focus on their preparation, both physical and psychological,” the team coach said.

Vasileva said that by time the World Cup starts, changes are expected in the team’s program in group exercises.

“We will work on an exercise with hoops. In general, if we talk about how exercises are put, then we start with an idea, someone can offer beautiful music, or the idea of costumes. For example, for an exercise with five hoops, after hearing a composition with national motifs, I thought that we should perform under it,” she noted.

Speaking about the competition, the coach highlighted that the team works hard and is glad to participate in any competitions.

Choreographer Guliyev said that the team’s programs in group exercises differ not only in the degree of complexity, but also in artistry.

“Compared to last year, this time our exercises were more difficult. I hope we will show a good result at the World Cup. In the meantime, we are still euphoric from the team’s victory at the European Championship. When we enter the training hall, a new stage will start for us. In the meantime, we are enjoying this moment, and I think we deserved it,” Guliyev said.

Speaking about the result of Aghamirova, her coach Vilyaeva stressed that she is a great fellow.

“When I found out about the results of Agamirova, I couldn’t hold back my tears. We have been working towards this for six years, and I am happy that we have succeeded,” Vilyaeva added.

Answering the question whether there is a leader in the team, the members of the senior team in the group exercises emphasized that the captain of the team is Laman Alimuradova.

“Each of us tries to support, help and advise each other because we are one team. We are all glad and happy that we managed to win the gold of the European Championship,” Alimuradova added.

“Yes, we are a united team and we know each other well, we feel when at a certain moment one of us needs support. This is the team spirit when we are always there,” Hummatova said.

“Each of us is unique, and we complement each other,” Luzan emphasized.

Aghalarzade noted that the won gold imposes even greater responsibility.

“Having won the gold medal at the European Championship, we understand that now we have to raise the bar, work even harder, and demonstrate the result even better,” she added.

Aghamirova also shared her impressions of participating in the European Championship.

“I tried to perform to the maximum, and of course, I was glad to win a medal. I want to thank everyone for their support because it inspires us all,” she added.

The 39th European Championship in Rhythmic Gymnastics was held on May 17-21 at the National Gymnastics Arena in Baku. Gymnasts from 38 countries were participating in the European Championship in Baku, held under the “Shine like a star” motto.

The Azerbaijani national team has five medals in the European Championship.

Two bronze medals – in the all-around and in the five-ball program, were won by the junior team in group exercises consisting of Govhar Ibrahimova, Sakinakhanim Ismailzada, Madina Aslanova, Ilahi Bahadirova, Ayan Sadigova, and Zahra Jafarova.

Moreover, gold in exercises with three ribbons and two balls, and bronze in the all-around, were won by the senior team in group exercises consisting of Gullu Aghalarzade, Laman Alimuradova, Kamilla Aliyeva, Zeynab Hummatova, Yelizaveta Luzan and Darya Sorokina, as well as a bronze medal – by Azerbaijani gymnast Zohra Aghamirova in the ball program.

Source: TREND News Agency